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KMID : 0369819950250040365
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Jorunal of Korean Pharmaceutical Sciences
1995 Volume.25 No. 4 p.365 ~ p.369
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Comparisons of the Two in Vitro Cytotoxicity Assays in Primary Cultured Rat Hepatocytes the Neutral Red (NR) and Lactate Dehydrogenase (LDH) Tests
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Abstract
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The acute cytotoxicities of chloroquine sulfate, propranolol, ascorbic acid, acetylsalicylic acid and acrylamide on culture adult rat hepatocytes were evaluated by the use of LDH leakage and NR uptake test. On the basis of IC50 values, the rank
order of
cytotoxicities of these drugs in both tests was chloroquine sulfate> propranolol> acetylsalicylic acid> ascorbic acid. The IC50 of LDH test was very similar to that of NR uptake test. Thus, we concluded that both tests are reliable and sensitive
methods
in detecting toxicity in adult cultured rat hepatocytes.
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